Plain-English translation of NCT07664371 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial compares three different ways to treat severe knee arthritis pain: cryoneurolysis (which freezes pain-causing nerves), pulsed radiofrequency (which uses electrical pulses), and cooled radiofrequency (which uses cooled electrical energy). All three treatments aim to reduce pain signals from the knee without surgery, and researchers want to see which one works best for people whose pain hasn't improved with standard medical care and physical therapy.
Many people with severe knee arthritis don't get enough pain relief from medications and physical therapy alone. This trial exists to find out whether these newer minimally invasive nerve treatments can safely and effectively reduce pain better than current options.
You likely qualify if…
You likely don't qualify if…
You would be randomly assigned to receive one of the three treatments. Each treatment is a minimally invasive procedure where doctors use either extreme cold or electrical energy to reduce the nerves causing your pain. The trial will track 30 participants total, and you would likely have follow-up visits to measure how much your pain improves compared to the other groups.
AI-generated summary from trial data · Aug 12, 2026 · Not medical advice
Egypt
Sponsor
Tanta University
Enrollment target
~30 participants
Started
June 2026
Primary completion
November 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in August 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Aliaa Mamdouh Abdelaziz Farag, MD
Tanta University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.