Plain-English translation of NCT07666815 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing whether combining physical exercise during dialysis with creatine monohydrate supplementation can help improve muscle strength, body composition, and physical function in people with stage 5 chronic kidney disease. You would be randomly assigned to one of four groups: some will receive both exercise and creatine monohydrate, some will receive exercise with a placebo (inactive) pill, some will exercise only, or some will receive standard dialysis care with no additions. The study lasts 8 weeks.
People on dialysis often lose muscle mass and become weaker, which affects their quality of life and overall health. This trial is trying to see if adding structured exercise and nutritional support during dialysis sessions could help preserve strength and improve how patients feel and function.
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You would attend your regular dialysis sessions three times per week for 8 weeks. Depending on which group you're assigned to, you may perform supervised exercises (like light resistance or aerobic activity) during some of your dialysis time, and you may take either the creatine supplement or a placebo pill. At the start and end of the 8-week period, the research team will measure your muscle mass, strength, and physical function through tests and blood work to see if the exercise and supplement helped.
AI-generated summary from trial data · Jun 29, 2026 · Not medical advice
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