Plain-English translation of NCT07671261 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a specialized brain stimulation device called deep brain stimulation (DBS) for people with schizophrenia who have not gotten better with multiple antipsychotic medications. Before implanting a permanent device, doctors will use temporary electrodes to map your brain activity and test which specific brain areas are most important for your symptoms. If testing shows the treatment is safe and helpful, you'll receive a permanent brain pacemaker-like device that delivers mild electrical stimulation to help reduce your psychotic symptoms.
Many people with schizophrenia don't respond well enough to standard antipsychotic medications, and their symptoms continue to severely affect their daily life and relationships. This trial aims to see whether carefully targeted brain stimulation, customized to each person's unique brain patterns, might help people who haven't had success with drugs alone.
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You will first have temporary electrodes placed in your brain under anesthesia to record your brain activity and test which areas should be stimulated. Over several weeks, doctors will test the effects of stimulation on your symptoms. If it works well and is safe, you'll have a permanent stimulation device surgically implanted. Then you'll be randomly assigned to either have the device turned on for 12 weeks followed by 12 weeks off, or vice versa, while researchers carefully monitor your symptoms and any side effects.
AI-generated summary from trial data · Jul 2, 2026 · Not medical advice
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