Plain-English translation of NCT07674277 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Sickle Cell Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether virtual reality headsets can help reduce pain and distress during vaso-occlusive crises—a serious complication of sickle cell disease where blood cells block blood vessels and cause severe pain. Participants will wear a VR headset during their regular infusion center visits to see if immersive 3D experiences can help manage pain alongside their standard pain medications. The goal is to find a safe, non-drug tool that works alongside opioids to help patients feel better during these painful episodes.
Many patients with sickle cell disease continue to suffer significant pain, stress, and loss of function even with strong pain medications. Researchers need to find additional, low-risk ways to help manage this pain—and virtual reality shows promise as a distraction tool that might reduce both pain and emotional distress.
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First, you'll meet with the study team at a regular sickle cell clinic visit when you're feeling well to sign consent forms and be randomized into a study arm. Then, during your next one or two infusion center visits for a vaso-occlusive crisis, you'll be offered the chance to wear a VR headset during your treatment—either a basic 2D version or an immersive 3D experience—while you receive your standard pain medications. The study team will check that it's safe for you to participate before each visit and will monitor how you respond to the virtual reality experience.
AI-generated summary from trial data · Oct 24, 2026 · Not medical advice
United States