Plain-English translation of NCT07675499 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Type 2 Diabetes research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This study is testing whether — insulin delivered as a nose spray — combined with exercise training works better than exercise alone for improving brain health in people with Type 2 Diabetes. Researchers want to see if this treatment improves blood flow to the brain, how the brain uses insulin, and thinking and memory skills. You'll be randomly assigned to either exercise with the medication or exercise with a placebo (fake) spray.
Type 2 Diabetes can affect how the brain works and may increase thinking and memory problems as people age. This research explores whether this medication, combined with physical activity, might protect brain function and improve blood flow to the brain in ways that exercise alone cannot.
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Over 16 weeks, you'll come to supervised exercise sessions 3 times per week — walking or light jogging — while using either the nasal insulin spray or a placebo spray daily at home. Before and after the program, you'll have brain imaging scans, memory and thinking tests, fitness assessments, and blood work to measure how the treatment affects your brain and overall health. The entire study takes about 4 months of your time.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
United States