Brain Stimulation Program for Menstrual and Pelvic Health Symptoms

The CREST study is testing a guided care program called the Samphire Guided Care Program for people with menstrual or pelvic health symptoms like premenstrual syndrome, endometriosis, or menopause-related mood and cognitive problems. The program includes an initial assessment by a women's health clinician, an optional at-home device called Lutea that uses gentle electrical brain stimulation, ongoing coaching support, and an app to track your symptoms. Researchers want to see whether this combination helps improve your mood, reduce brain fog, and help you work and feel better overall.

Many people with menstrual and pelvic health conditions struggle with mood changes, difficulty concentrating, and fatigue that interfere with work and daily life. This trial is testing whether adding guided support and optional brain stimulation can provide real relief and help people feel and function better.