Plain-English translation of NCT07680452 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether eating more fiber and taking short fasting breaks can help immunotherapy work better for melanoma (a type of skin cancer). Immunotherapy with checkpoint inhibitors helps your immune system fight cancer cells, but researchers want to know if diet changes might boost its effectiveness and reduce side effects. This study will look at whether these lifestyle changes are practical and whether they affect quality of life, fatigue, treatment side effects, and how your body responds.
Immunotherapy has greatly improved melanoma treatment, but doctors still want to find ways to make it work even better while causing fewer side effects. Early research suggests that diet—especially eating more fiber and doing short fasting periods—might help the medication work more effectively by changing gut bacteria and reducing harmful reactions.
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If you join, you'll be placed into one of three groups: one group will eat a high-fiber diet only, another will eat a high-fiber diet and do short 72-hour fasting periods during each immunotherapy cycle, and a third group will continue with their normal diet as a comparison. Throughout your participation, researchers will check on your quality of life, tiredness levels, how well you tolerate the medication, disease progression, and changes in your gut bacteria through blood tests and stool samples.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
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