Plain-English translation of NCT07681466 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Migraine research guide →Researchers want to understand what happens in the hours or days before a migraine attack begins. Many people with migraine experience early warning signs—like fatigue, mood changes, or food cravings—before the headache pain starts. This study will ask you to carefully track these early symptoms across up to 5 of your migraine attacks using an electronic diary, so scientists can map out the exact order in which these warning signs appear and learn when might be the best time to treat a migraine before it gets worse.
Right now, doctors don't fully understand the sequence of early warning symptoms that signal the start of a migraine attack. Knowing which symptoms appear first, and in what order, could help identify an earlier window for treatment—potentially stopping the attack before the worst pain begins.
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You will use a structured electronic diary (likely on your phone or computer) to record any early warning symptoms you notice before up to 5 of your migraine attacks. The researchers want you to note what symptoms appear, when they appear, and in what order—all before your headache pain starts. This is a tracking study, so there are no medications to take or procedures to undergo; you are simply documenting your own experience to help scientists understand how migraine attacks begin.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
Italy
Sponsor
University of Roma La Sapienza
Collaborators
IRCCS National Neurological Institute "C. Mondino" Foundation, University of Modena and Reggio Emilia
Enrollment target
~500 participants
Started
March 2026
Primary completion
March 2027
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in July 2026.
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Central contact
Gabriele Sebastianelli, MD
University of Roma La Sapienza
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.