Testing rapid vaccine response to prevent cholera spread in Bangladesh

This trial is testing a strategy called Case-area Targeted Interventions (CATIs) to control cholera outbreaks in Bangladesh. When cholera cases are detected, the study will rapidly vaccinate people living in the affected household and neighboring homes using the oral cholera vaccine (OCV). The goal is to see if this fast, targeted approach can reduce cholera transmission better than waiting for standard outbreak responses.

Cholera kills tens of thousands of people every year in Asia, Africa, and Latin America, and standard vaccination campaigns are slow and expensive. Researchers want to know if catching cases early and immediately vaccinating nearby households can stop the disease from spreading faster and more effectively than current methods.