Plain-English translation of NCT07686835 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing whether dietary fiber — specifically from dried chicory roots — can help boost your body's natural immune response to immunotherapy. Researchers believe that fiber may help grow healthy bacteria in your gut that make immunotherapy work better. You would take the fiber supplement (or a placebo that looks identical) while receiving your standard immunotherapy treatment.
Previous studies suggest that people who eat more fiber may respond better to immunotherapy for melanoma, but doctors aren't certain yet. This trial will help clarify whether adding fiber to your diet can truly improve how well this treatment works for you.
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You would receive either dried chicory root fiber or a placebo (a look-alike with no active ingredient) to take daily while you receive your standard immunotherapy treatment. The study is double-blinded, meaning neither you nor the research team will know which group you're in. You'll be asked to provide stool samples at different time points so researchers can check whether the fiber is changing your gut bacteria, and you'll have regular clinic visits as part of your standard cancer care.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
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