Plain-English translation of NCT07691138 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether patients with inflammatory bowel disease (ulcerative colitis or Crohn's disease) can safely stop taking proton pump inhibitors (PPIs)—common acid-reflux medications—without their bowel disease getting worse. The study will help researchers understand if stopping this medication is safe and practical, so they can plan a larger study in the future.
Many people with inflammatory bowel disease take acid-reflux medication long-term, but doctors aren't sure if everyone really needs to keep taking it forever. This medication can have side effects with long-term use, so understanding whether patients can safely stop it could improve their overall health.
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You will be randomly assigned to either continue taking your acid-reflux medication or gradually stop taking it. You'll answer questions about your bowel symptoms and overall digestive health at different time points. Some participants will also be invited to take part in an online interview (lasting up to one hour) to share their experience with the study and how they felt about stopping or continuing the medication.
AI-generated summary from trial data · Jul 13, 2026 · Not medical advice
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