Plain-English translation of NCT07696351 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether GnRH-a (a hormone-suppressing medication) given before a frozen embryo transfer can improve the chances of pregnancy in women with deep infiltrating endometriosis—a severe form of the condition where tissue grows into pelvic organs. The study compares women who receive the medication before transfer to women who receive standard preparation without it. About 120 women will participate.
Deep infiltrating endometriosis can make it harder for embryos to implant and increases the risk of miscarriage. Doctors think this medication might reduce inflammation and create a better environment in the uterus for the embryo, but there isn't enough strong evidence yet to know if it truly helps.
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If you join the treatment group, you will receive two hormone injections about one month apart, starting early in your menstrual cycle. About one month after the second injection, you will begin hormone therapy to prepare your uterus, and then have your frozen embryo transferred as usual. If you join the comparison group, you will have standard hormone preparation and embryo transfer without the initial injections. Either way, the study team will follow your pregnancy outcomes over time.
AI-generated summary from trial data · Aug 28, 2026 · Not medical advice
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