Recruiting

Testing a new injection for nasal polyps without steroid sprays

Plain-English translation of NCT07701967 on ClinicalTrials.gov ↗ · Source last updated September 2026 · Translation generated September 2026 · How we translate trials

Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.

What is this trial?

This study is testing a medication called , given as an injection under the skin, to see if it can help people with chronic nasal polyps and sinus inflammation. The trial is specifically looking at whether the medication works well on its own, without needing to use steroid nasal sprays at the same time. Researchers want to understand how safe and effective this treatment is for Japanese patients whose nasal polyp symptoms haven't improved with their current care.

Many people with chronic nasal polyps continue to have troubling symptoms even after using standard treatments like steroid sprays and other medications. This trial exists to see whether this medication could offer a better option for patients who aren't getting enough relief, especially those who can't use or don't tolerate steroid treatments well.

Do you qualify?

You likely qualify if…

you are 18 years of age or older
you have been diagnosed with chronic nasal polyps that are causing moderate to severe symptoms like nasal congestion, difficulty smelling, or runny nose
your nasal polyp symptoms have not improved adequately with standard treatments
you have had previous nasal surgery for polyps, taken systemic steroids for nasal polyps in the past, or cannot tolerate steroid medications
your chronic sinus symptoms have been present for at least 12 weeks before enrolling in the study

You likely don't qualify if…

you have cystic fibrosis or fungal sinus infections
you have a nasal tumor (cancerous or non-cancerous) or severe nasal septal deviation
you have had nasal or sinus surgery within the past 6 months
you have had an acute sinus infection or upper respiratory infection in the 2 weeks before screening
you have a condition that causes very high eosinophil levels (like EGPA or eosinophilic esophagitis) or an untreated parasitic infection

What participation looks like

If you join this trial, you will receive the new medication as an injection under your skin while continuing your other regular sinus treatments (except steroid nasal sprays). The study will involve visits where doctors examine your nasal polyps, assess your symptoms, and monitor how well the treatment is working and check for any side effects. The trial is designed for about 28 participants total, and you would be followed to see whether this medication helps reduce your polyp symptoms without needing steroid sprays.

AI-generated summary from trial data · Sep 24, 2026 · Not medical advice

Trial locations(10 sites)

Japan

GSK Investigational Site, Ehime

GSK Investigational Site, Fukui

GSK Investigational Site, Fukuoka

GSK Investigational Site, Gunma