Plain-English translation of NCT07710287 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are testing whether a new laboratory technique called Claudin 2 immunostaining can more accurately detect inflammation in bowel biopsies than current standard methods. This study includes people with ulcerative colitis or Crohn's disease who are already having endoscopy (a procedure where doctors look inside your bowel and take small tissue samples). The goal is to see if this new staining method could help doctors better understand your disease and predict how well you'll do over time.
Doctors currently use several different scoring systems to look at tissue samples from the bowel, but they don't always agree with each other. This study exists to find out if the new Claudin 2 staining method is more accurate and reliable, which could help doctors make better treatment decisions for people with inflammatory bowel disease.
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If you join this study, you'll have a standard endoscopy procedure where small tissue samples are collected from your bowel — something many IBD patients already do regularly. These samples will be stained using both the new Claudin 2 method and traditional scoring methods so researchers can compare them. You'll then be followed for one year, with doctors tracking your symptoms, blood work, and any changes to your treatment to see if the new staining method helps predict how you'll do.
AI-generated summary from trial data · Aug 6, 2026 · Not medical advice
Italy
Sponsor
IRCCS Policlinico S. Donato
Collaborators
Asst Degli Spedali Civili Di Brescia
Enrollment target
~100 participants
Started
February 2025
Primary completion
February 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Vito Annese, Prof. PI
IRCCS Policlinico S. Donato
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.