Testing a new injection to treat scarring hair loss

Plain-English translation of NCT07734870 on ClinicalTrials.gov ↗ · Source last updated September 2026 · Translation generated September 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This clinical trial is testing whether , a medication given by weekly injection, can help treat central centrifugal cicatricial alopecia (CCCA) — a condition that causes permanent scarring and hair loss. Researchers want to understand whether this medication can slow or stop the hair loss, reduce symptoms like scalp pain and itching, and even promote new hair growth.

CCCA is a serious condition that currently has limited treatment options. This medication has shown promise in other conditions, and researchers believe it may help reduce the scarring and inflammation that cause hair loss in CCCA.

Do you qualify?

You likely qualify if…

you are between 18 and 80 years old
you have been diagnosed with active central centrifugal cicatricial alopecia (confirmed by a doctor or skin biopsy)
you have not received treatment for this hair loss condition in the past 6 weeks
you are able to give yourself weekly injections and attend clinic visits for 12 months
you will be managed by a Johns Hopkins dermatologist throughout the study

You likely don't qualify if…

you are currently taking diabetes medications or weight-loss medications
you are pregnant, breastfeeding, or planning to become pregnant
you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2
you have a history of kidney disease, pancreatitis, or severe stomach problems
you have a history of poor wound healing, blood clotting problems, or keloid scarring

What participation looks like

You would give yourself a weekly injection under the skin for 12 months, starting with a lower dose for the first month and then increasing it. You'll visit the clinic regularly for scalp examinations and photographs, and you'll have small skin samples (biopsies) taken from your scalp at the beginning and after 6 months. You'll also have blood tests and safety monitoring throughout the year to make sure the medication is working safely.

AI-generated summary from trial data · Sep 24, 2026 · Not medical advice

Testing a new injection to treat scarring hair loss

What is this trial?

Do you qualify?

What participation looks like

Trial locations