Plain-English translation of NCT07735182 on ClinicalTrials.gov ↗ ·
This research study is investigating whether changes in your gut bacteria (the microorganisms that live in your intestines) can help predict or explain why some people with severe infections develop liver and kidney damage. Researchers will collect stool and blood samples from patients with severe infection at several time points over three weeks, and compare them to samples from healthy volunteers. The study hopes to find patterns that might lead to better ways to prevent or treat these serious complications.
Severe infection causes significant harm in hospitals, and many patients develop liver or kidney damage as a result—but we don't fully understand why this happens. Recent research suggests that changes in the bacteria living in the gut may play an important role, so this study aims to gather evidence about that connection and potentially identify patients at higher risk.
You likely qualify if…
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If you are a patient with severe infection, you will have stool and blood samples collected at enrollment and then at three additional time points over the next three weeks (roughly days 3–5, 7–10, and 14–20). If you are a healthy volunteer, you will provide one stool and blood sample at enrollment. Researchers will analyze these samples to measure your gut bacteria, blood chemicals, and markers of organ function to understand the connection between changes in gut bacteria and organ damage during severe infection.
AI-generated summary from trial data · Aug 25, 2026 · Not medical advice
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