Plain-English translation of NCT07742982 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a combination approach to treat focal vitiligo—a condition where your skin loses its color and develops white patches. You would receive six laser treatments over several months, and immediately after each laser session, you would apply either 5-Fluorouracil or L- cream to help stimulate your skin's natural color-restoring cells. The goal is to see which combination works best to bring color back to the white patches.
Current treatments for vitiligo don't work well enough for everyone, and many people still struggle with white patches even after trying available options. This trial is exploring whether combining laser therapy with this medication might offer a better, more effective choice for people with focal vitiligo.
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You will visit the clinic six times over about three months, with visits spaced two weeks apart. At each visit, you'll receive a fractional laser treatment on your white patches—this uses a special laser to gently treat the skin without damaging surrounding areas. Immediately after each laser session, you'll start applying either 5-Fluorouracil or L- cream (depending on which group you're assigned to) once or twice daily for two weeks. You'll continue this cycle for all six treatment sessions, with researchers checking your progress and taking photos to measure how much color returns to your skin.
AI-generated summary from trial data · Aug 25, 2026 · Not medical advice
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