Plain-English translation of NCT07743944 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →This is a real-world observational study that tracks patients with advanced hormone-sensitive, HER2-negative breast cancer who are starting or have recently started their second line of cancer treatment. The study combines past medical records with ongoing follow-up to understand which treatments doctors prescribe and how well they work for patients in China. By gathering this information from actual clinical practice, researchers hope to better understand what treatment patterns lead to the best outcomes.
Current knowledge about how second-line treatments work in real-world settings—outside of controlled clinical trials—is limited. This study exists to fill that gap by learning what treatments are actually used, how patients respond, and what outcomes they experience, so doctors can make better treatment decisions for future patients.
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As a participant, you would allow the research team to access and review your medical records—both from before you enrolled and going forward—to document your treatment and how you respond to it. The study has both a retrospective part (looking back at your past care) and a prospective part (following you over time). You would not receive an experimental medication; instead, you would receive whatever treatment your doctor prescribes as part of your regular care, and the researchers would simply track and learn from your experience.
AI-generated summary from trial data · Sep 1, 2026 · Not medical advice
China
Sponsor
AstraZeneca
Enrollment target
~2,000 participants
Started
August 2026
Primary completion
August 2031
Age range
18 Years and older
Last updated on clinicaltrials.gov in August 2026.
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Central contact
Astra Zeneca Clinical Study Information Center
AstraZeneca
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