Plain-English translation of NCT07745374 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether deep brain stimulation (DBS)—a surgically implanted device that sends electrical signals to a specific part of the brain—can safely treat severe depression in people with bipolar I disorder. The study also uses real-time monitoring of brain signals to track depression and predict mood switches, aiming to personalize the treatment and keep it safe.
Many people with bipolar disorder have severe depression that doesn't improve with standard medications and treatments. However, doctors worry that treating this depression might trigger a manic episode. This trial is exploring whether this new treatment approach can ease depression while using brain monitoring to prevent dangerous mood swings.
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You would undergo brain surgery to have the device implanted, then stay in the New York area for frequent monitoring during the first 6 months. The device would send electrical signals to your brain and continuously monitor your brain activity to track your mood. You would have regular visits with the study team and your psychiatrist to adjust the device and monitor your response and safety.
AI-generated summary from trial data · Aug 6, 2026 · Not medical advice
United States