Recruiting

Testing brain stimulation for Parkinson's disease symptoms

Plain-English translation of NCT07745673 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a newer approach called temporal interference stimulation (TIS)—a non-invasive way to stimulate specific areas deep in the brain—to see if it can help reduce the motor symptoms of Parkinson's disease. Researchers want to compare whether stimulating one of two different brain areas (the subthalamic nucleus or the globus pallidus) produces better results. The goal is to understand which brain target works better and how this treatment affects brain activity and movement control.

Parkinson's disease causes problems with movement, tremors, and stiffness that can significantly affect quality of life. While current treatments like medications help some patients, doctors are looking for new ways to provide relief. This trial is testing whether this non-invasive brain stimulation technique could offer another option for people with Parkinson's.

Do you qualify?

You likely qualify if…

you are at least 40 years old
you have been diagnosed with idiopathic Parkinson's disease according to established criteria, with symptom onset at age 40 or later
you have been treated with dopamine replacement therapy (such as levodopa) and have responded well to it
you can walk independently for at least 5 minutes without assistive devices
you have had Parkinson's disease for at least 2 years and are clinically stable

You likely don't qualify if…

you have mild cognitive impairment or more severe memory or thinking problems
you have a history of epilepsy, traumatic brain injury, or implanted metal devices in your brain or heart
you have claustrophobia or other contraindications to MRI scans
you are currently taking antipsychotic or antidepressant medications that affect dopamine levels
you have severe freezing of gait (sudden inability to move your legs)

What participation looks like

If you enroll, you'll receive 20-minute brain stimulation sessions once per day for 7 consecutive days. Before and after each session, researchers will assess your movement and motor symptoms using standardized tests. You'll also have brain imaging (MRI) and brain activity monitoring (EEG) done before your first session and after your last session. The entire study commitment is about one week of daily visits, plus the imaging appointments.

Testing brain stimulation for Parkinson's disease symptoms

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)