Plain-English translation of NCT07746635 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether fecal microbiota transplantation (FMT)—a capsule containing healthy bacteria from donated stool—can help obese women with polycystic ovary syndrome (PCOS) improve their fertility and metabolic health. PCOS is a hormonal condition that affects the ovaries and can make it harder to get pregnant. The study looks at whether restoring healthy gut bacteria through this medication might improve egg quality and pregnancy chances, especially for women undergoing fertility treatment.
Women with PCOS often have imbalanced gut bacteria, insulin resistance, and inflammation—all of which can reduce fertility and harm egg quality. This medication offers a new way to restore healthy gut bacteria and might improve the body's metabolism and hormone balance, which could lead to better pregnancy outcomes.
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If you are accepted into Phase 2 (the main study), you will be randomly assigned to receive either capsules containing healthy gut bacteria or matching placebo capsules. You will take 5 capsules twice daily on an empty stomach for 6 days, then wait 4 weeks, and repeat this cycle two more times. Throughout the study, you'll receive guidance on diet and lifestyle, and researchers will monitor your gut bacteria, metabolic health, and fertility outcomes when you undergo your embryo transfer procedure. The entire study takes several months.
AI-generated summary from trial data · Sep 20, 2026 · Not medical advice
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