Plain-English translation of NCT07756723 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial compares two approaches to help veterans who are struggling with both PTSD and substance use problems. One group will learn a breathing technique called Heart Rate Variability Biofeedback (HRVB) that teaches you to breathe at a specific pace to calm your nervous system and reduce stress. The other group will receive standard talk therapy focused on present-day life challenges. Both treatments are combined with trauma-informed counseling to help you develop better coping skills.
Veterans with PTSD and substance use disorder face serious health risks, including heart disease and early death. Researchers want to find out whether the breathing training can help reduce both PTSD and substance use symptoms better than the traditional talk therapy approach, potentially improving your overall health and life expectancy.
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You will attend an initial visit where you'll complete some questionnaires and testing, then be randomly assigned to either the breathing training group or the talk therapy group. You'll attend six weekly sessions of your assigned treatment, during which you'll learn new techniques and practice them with a therapist. Throughout the study, you'll complete surveys and have your heart rate and stress levels measured to help researchers track how well the treatment is working for you.
AI-generated summary from trial data · Aug 13, 2026 · Not medical advice
United States