Testing inhaled medication to reduce chronic migraine frequency

This trial is testing whether dexmedetomidine, given as an inhaled mist through a nebulizer, can help reduce chronic migraines. Researchers believe this medication may work by calming down the nervous system's pain signals in people whose migraines have become frequent (15 or more days per month). The study will measure whether this treatment can decrease both how often migraines happen and how sensitive the nervous system becomes to pain.

Chronic migraines are often caused by the nervous system becoming overly sensitive to pain signals, a process that gets worse over time. Current treatments don't work well for everyone, so researchers are exploring whether this medication, delivered directly to the lungs through inhalation, might offer a new way to calm down these pain signals and prevent migraines from becoming chronic.