Plain-English translation of NCT07776444 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Sickle Cell Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study uses two types of advanced brain imaging — specialized MRI scans and a special imaging cap called HD-DOT — to measure how much oxygen reaches your brain tissue and how well your brain's blood vessels respond to changes. Researchers want to find early warning signs that brain tissue is at risk for damage, especially in people with sickle cell disease or stroke. This information could help doctors predict and prevent future strokes.
People with sickle cell disease and stroke survivors are at higher risk for brain injury, but doctors don't yet have reliable ways to spot which patients are in danger before damage happens. This study is testing whether these imaging measurements can identify brain tissue under stress before a permanent stroke occurs.
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You will come for MRI brain scans where you lie still while the machine takes pictures. During one scan, you will breathe air with a slightly higher carbon dioxide level through a special breathing device called RespirACT, which helps doctors measure how your brain's blood vessels respond. You will also wear a special imaging cap on your head during some measurements. The study compares people with sickle cell disease to healthy volunteers to understand the differences in how their brains handle oxygen.
AI-generated summary from trial data · Aug 21, 2026 · Not medical advice
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