Testing magnesium versus standard pain relief for emergency headaches

This trial is testing whether intravenous magnesium sulfate—a mineral that may help calm overactive nerve activity and reduce pain—can effectively treat severe acute headaches in the emergency department. Researchers want to find out if magnesium sulfate works better than paracetamol (a standard pain reliever) and whether a higher dose might be more effective than a lower dose.

Many people come to emergency departments with severe headaches, but current pain medications don't always work well enough. This medication shows promise because it may target the root causes of headaches by affecting nerve signals and blood vessel function, but doctors need to know if it really works and what dose is best.