Plain-English translation of NCT07791849 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
This study doesn't follow the usual testing phases โ it may be an observational study or a different type of research.
After a stem cell transplant, doctors typically give patients a medication called a proton pump inhibitor to protect the stomach. This trial is testing whether switching to a different stomach-protecting medication called after transplant might work better. The goal is to see if the new medication reduces a serious complication called acute graft-versus-host disease while also preserving the healthy bacteria in your gut.
The standard stomach-protecting medication, while helpful, can reduce stomach acid and change the bacteria in your gut in ways that might increase the risk of graft-versus-host disease. This medication works differently โ it strengthens the stomach lining without affecting stomach acid โ so it may protect your stomach while preserving your gut bacteria and reducing complications.
You likely qualify ifโฆ
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You will be randomly assigned to one of two groups. One group will take the standard stomach-protecting medication during conditioning, then switch to three times daily for 100 days after transplant. The other group will continue the standard medication for the full 100 days after transplant. You will be monitored closely throughout this period, and researchers will collect saliva and stool samples to track changes in your gut bacteria and watch for any side effects or complications.
AI-generated summary from trial data ยท Sep 11, 2026 ยท Not medical advice
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