Brain Stimulation to Help Tell Self From Others in Schizophrenia

Plain-English translation of NCT07818668 on ClinicalTrials.gov ↗ ·

What is this trial?

This trial is testing a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) to help people with schizophrenia improve their ability to tell the difference between themselves and others. People with schizophrenia sometimes struggle with this distinction, which can contribute to some of their symptoms. Researchers believe that applying gentle electrical pulses to a specific brain region for a few minutes each day might help restore this ability.

Many people with schizophrenia have trouble distinguishing their own thoughts and identity from other people's, which can worsen hallucinations and delusions. Currently available treatments don't fully address this core problem, so researchers are exploring whether this non-medication approach could offer a new option.

Do you qualify?

You likely qualify if…

you have been diagnosed with schizophrenia or schizoaffective disorder according to current diagnostic standards
you are experiencing hallucinations or delusions
you are between 18 and 50 years old
you have been stable on the same antipsychotic medication for at least 4 weeks with no planned changes during the study
you have normal or corrected-to-normal vision (able to see at least 20/40)
you are able to understand the study and provide written consent

You likely don't qualify if…

you have a history of neurological disorders such as epilepsy, stroke, or traumatic brain injury
you have other major psychiatric disorders such as bipolar disorder or major depression
you have metal implants in your head or skull (such as cochlear implants or deep brain stimulators)
you have a history of substance dependence or abuse in the past 6 months
you are pregnant, breastfeeding, or have skin lesions or wounds where the electrodes would be placed on your scalp

What participation looks like

You would attend sessions over about a week where researchers place small electrodes on your scalp and apply gentle electrical stimulation for 20 minutes per day for 5 consecutive days. Before, during, and after this treatment, you'll complete face-recognition tasks on a computer while your brain activity is recorded with an EEG cap (a non-invasive electrode net on your head). You'll also complete questionnaires about your experiences, and return for a follow-up visit 48 hours after your final stimulation session.

Brain Stimulation to Help Tell Self From Others in Schizophrenia

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)