Plain-English translation of NCT07825818 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This research study uses advanced brain imaging technology to look at how alcohol affects the brain's ability to produce and use energy. Researchers will scan both people who struggle with alcohol use and healthy volunteers to understand the differences in brain function. The goal is to learn more about what happens in the brain during alcohol use disorder and why some people relapse.
Scientists believe that problems with how the brain produces energy may play a role in alcohol addiction and relapse. By studying this directly with imaging, researchers hope to better understand the biological reasons behind alcohol use disorder and eventually develop better treatments.
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You would come to the research center for imaging visits where you'll receive two types of brain scans: one that measures energy production in the brain and another that measures glucose (sugar) use. The study involves an arterial line (a small tube placed in your wrist artery) to collect blood samples during the scans. For people in the alcohol use disorder group, the researchers will follow your progress to see if the brain imaging measures relate to whether you return to drinking.
AI-generated summary from trial data · Sep 17, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Rajesh Narendran
Collaborators
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Enrollment target
~100 participants
Started
September 2026
Primary completion
December 2032
Age range
18 Years – 55 Years
Last updated on clinicaltrials.gov in September 2026.
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Central contact
Rajesh Narendran
University of Pittsburgh
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