Strength training to help knee arthritis and boost body's repair factor

This trial investigates how resistance exercises (strength training) affects a natural growth factor in your body called IGF-1, which helps repair cartilage in arthritic knees. Researchers want to understand whether this protein plays a role in why strength training helps some people with knee arthritis feel better, and whether having related metabolic health conditions (like high blood pressure, extra weight, or blood sugar issues) changes how well the exercises work.

Doctors know that strength training helps people with knee arthritis, but they don't fully understand how it works at the biological level. This research aims to fill that gap and learn whether treating patients with related metabolic conditions differently might improve their results.