Recruiting

Comparing two surgical approaches for large bladder tumors

Plain-English translation of NCT07898033 on ClinicalTrials.gov ↗ · Source last updated October 2026 · Translation generated November 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing whether a newer surgical technique called modified en bloc resection (ERBT) works better than the standard approach called transurethral resection (TURBT) for removing large bladder tumors that are bigger than 2.5 centimeters. Both are minimally invasive surgical procedures performed through the urethra, but they remove the tumor in slightly different ways. The study will compare how well each approach prevents the tumor from coming back within one year.

Doctors want to know if the newer ERBT technique can reduce the chance of bladder cancer returning compared to the traditional TURBT method, especially for larger tumors where recurrence can be a problem.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with a bladder tumor larger than 2.5 centimeters that is suspected to be early-stage (non-muscle invasive) bladder cancer
you are in good enough health to undergo endoscopic surgery, with a performance status score of 2 or lower
you have signed an informed consent form agreeing to participate in the study

You likely don't qualify if…

you have four or more separate tumors in your bladder
you have previously had bladder cancer that did not respond to BCG therapy
you have received chemotherapy or immunotherapy for any cancer in the past
you have evidence that cancer has spread to other parts of your body
you are unable to have endoscopic bladder surgery for medical reasons

What participation looks like

You will be randomly assigned to receive either the ERBT or TURBT surgical procedure to remove your bladder tumor. Both surgeries are performed through the urethra and do not require large incisions. After surgery, you will be monitored for one year to track whether your tumor returns, with follow-up visits to check your recovery and monitor your bladder health.

AI-generated summary from trial data · Nov 3, 2026 · Not medical advice

Trial locations(1 site)

Israel

Rabin Medical Center, Petah Tikva

Comparing two surgical approaches for large bladder tumors

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)

Key details

Contact the research team directly

Interested in joining?