Combining two cancer treatments before liver transplant for hepatocellular carcinoma

This trial is testing whether combining transarterial chemoembolization (TACE) and stereotactic body radiation therapy (SBRT) works better than TACE alone in preparing patients with liver cancer for a liver transplant. TACE is a procedure that delivers cancer-fighting drugs directly to the tumor through blood vessels, while SBRT is a targeted radiation therapy. Early research suggests that using both treatments together may help shrink tumors more effectively before transplant.

Many patients with liver cancer cannot have surgery to remove the tumor because their liver is too damaged. While waiting for a liver transplant—which can take months—the cancer may grow and make transplant impossible. This trial is exploring whether combining two different treatments can better control the cancer during the waiting period.