ALS

June 2026 Research Brief

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Trials

Device

Robotic upper limb rehabilitation system tested for safety and effectiveness in adults with Parkinson's disease, ALS, stroke, and cognitive impairment.

Auto-calibrating System for Upper Limb Disability Assessment, Neurological and Occupational Rehabilitation

University of PaviaPosted: Jun 2026NCT07636538 ↗

Cira Fundarò, MDcira.fundaro@icsmaugeri.it

Neuroprotection

Mediterranean-DASH diet intervention tested for feasibility and benefit in people with ALS and Parkinson's disease.

The Meals Study for Amyotrophic Lateral Sclerosis and Parkinson's Disease

The University of Tennessee, KnoxvillePosted: Jun 2026NCT07625605 ↗

Gene therapyPh 1

Gene therapy injection delivering neurotrophic factor tested for safety and efficacy in ALS patients.

Safety and Efficacy of Intrathecal NTF001 Injection in ALS

Ruijin HospitalPosted: Jun 2026NCT07618585 ↗

Exercise intervention

Virtual reality cycling system with cognitive exercises tested for usability and motivation in neurological patients.

Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients

Marta MondelliniPosted: May 2026NCT07616050 ↗

Marta Mondellini, Psychologistmarta.mondellini@cnr.it

Drug / intervention

Electrical nerve stimulation of the throat tested to improve swallowing frequency in ALS patients.

Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow in Patients Living With ALS

Nova Southeastern UniversityPosted: May 2026NCT07606235 ↗

Racquel Garcia, SLPD, CCC-SLPrw602@nova.edu

Device

New NeuroEXPLORER PET/CT scanner compared to standard scanner for diagnostic value in head and neck imaging.

Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.

prof. dr. Koen Van LaerePosted: May 2026NCT07595666 ↗

Drug / intervention

Electrical stimulation applied to facial muscles reduces pain and improves chewing in ALS and PLS patients.

Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.

Nova Southeastern UniversityEst. completion: Aug 2026NCT07187388 ↗

Kayla Chomko, PT, DPTkayla.chomko@nova.edu

Drug / interventionPh 1

Prosetin drug safety and dosage evaluated in healthy volunteers and ALS patients.

A Study to Evaluate the Safety and Pharmacokinetics of Single and Multiple Doses of Prosetin in Healthy Volunteers and Participants With ALS

ProJenXEst. completion: Jun 2026NCT05279755 ↗

Drug / interventionPh 2

ARGX-119 drug tested for safety and muscle function in adult ALS patients.

A Safety and Efficacy Study of ARGX-119 in Adult Patients With Amyotrophic Lateral Sclerosis (ALS)

argenxEst. completion: Aug 2026NCT06441682 ↗

Device

Mechanical insufflator-exsufflator device tested to slow cough decline in early ALS patients.

Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study

University of PennsylvaniaEst. completion: Jun 2026NCT06119087 ↗

Showing trials with activity in the past 30 days. See the full ALS research landscape →

Recently completed · awaiting results

Drug / intervention

Study examines social cognition impairments in ALS patients.

Social Cognition in Patients With Amyotrophic Lateral Sclerosis

University Hospital, AngersEst. completion: May 2026NCT04406675 ↗

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ALS — the full picture

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