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Long COVID

June 2026 Research Brief

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Trials

Rehab / exercise
Physical rehabilitation program improves handgrip strength and walking ability in long COVID patients.

Effects of a Physical Rehabilitation Program on Long COVID

Universidade do Estado do ParáPosted: Jun 2026NCT07651371
Immune modulationPh 2
Paragon Novel Metabolic Regulator plus standard care treats long COVID symptoms over six weeks.

Evaluating the Safety and Efficacy of PNMR as Treatment for Long COVID

ParagonClinicals Inc.Posted: Jun 2026NCT07627815
Samuel H. O. Bock / CSO, BA Environmental Sciencesbock@paragonsciences.com
Rehab / exercise
Diaphragmatic breathing exercises with electrical stimulation treat breathing problems in long COVID patients.

Diaphragmatic Breathing Exercises With KOTS Currents in Patients With Long COVID

Universidad Pontificia de SalamancaPosted: Jun 2026NCT07621588
Sara Perpiña-Martinezsperpinama@upsa.es
Cognitive / neurological
At-home MMT device treats cognitive dysfunction from long COVID, brain injury, and neurodegenerative diseases.

Fareon Open Label Device Clinical Trial

Icahn School of Medicine at Mount SinaiPosted: May 2026NCT07600320
David Putrino, PhDCoreResearch@mountsinai.org
AntiviralPh 2
Combination of valacyclovir, celecoxib, and Paxlovid reduces long COVID symptoms in adults.

SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction

Icahn School of Medicine at Mount SinaiPosted: May 2026NCT07597902
David Putrino, PhDCoreResearch@mountsinai.org
Diagnostics
Investigation of whether long COVID patients retain inactive viral remnants after infection recovery.

Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection

National Institute of Neurological Disorders and Stroke (NINDS)Est. completion: Sep 2026NCT06577467
Angelique A Gavinangelique.gavin@nih.gov
Cognitive / neurologicalPh 2
Drug NE3107 tested against placebo for neurological symptoms like brain fog in long COVID.

NE3107 in Adults With Neurological Symptoms of Long COVID

BioVie Inc.Est. completion: Aug 2026NCT06847191
Rehab / exercise
Computerized brain-training exercises tested as treatment for Long COVID symptoms in older adults.

Brain-Training Treatment for Long COVID in Older Adults

UConn HealthEst. completion: Jun 2026NCT05705193
DevicePh 2
Anktiva treatment examined for safety and effectiveness in patients with persistent Long COVID symptoms.

A Study to Examine Anktiva for the Treatment of COVID-19.

ImmunityBio, Inc.Est. completion: Jul 2026NCT07123727
Fatigue
Study comparing mitochondrial energy-producing capacity in blood, muscle, and skin cells between Long COVID and recovered patients.

Mitochondrial Function in Peripheral Blood Mononuclear Cells, Muscle, and Skin of Long COVID Patients

Universitair Ziekenhuis BrusselEst. completion: Jul 2026NCT07134673
Berenice G. Jimenez Garcia, Master of Scienceberenice.gabriela.jimenez.garcia@vub.be

Showing trials with activity in the past 30 days. See the full Long COVID research landscape →

Condition guide

Long COVID — the full picture

Research landscape, trial types, and what eligibility typically looks like — written for patients but useful for everyone.

Read the condition guide →

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