Infertility affects about one in six couples trying to conceive. Treatment options range from medication that stimulates ovulation to in vitro fertilization (IVF), where eggs are fertilized outside the body and transferred to the uterus. Success rates have improved steadily, and research is working to make treatment safer, more effective, and accessible to more people.
What's actually going on in research
Trials are testing ways to improve egg and sperm quality, develop better embryo selection methods, reduce complications like ovarian hyperstimulation, and address specific causes like endometriosis and male factor infertility. Researchers are also studying mitochondrial health in eggs, new hormonal protocols for ovulation induction, and genetic screening techniques that may improve pregnancy rates without increasing multiple births.
Embryo selection technology
New imaging and genetic testing methods aim to identify which embryos are most likely to result in pregnancy. The goal is higher success rates per IVF cycle while reducing the number of embryos transferred and avoiding multiple pregnancies.
Endometriosis treatment
Studies are testing whether treating endometriosis before IVF improves outcomes, and whether new medications can preserve fertility in women with the condition. Some trials focus on inflammation pathways that may link endometriosis to infertility.
Male factor approaches
Trials are examining antioxidant supplements, hormonal treatments, and techniques to select healthier sperm. Research is also exploring genetic causes of low sperm count and poor sperm quality.
What to know before you search
Eligibility typically depends on age, duration of infertility, ovarian reserve testing, sperm analysis results, and whether prior fertility treatments have been tried.
What types of trials are currently open
- IVF protocol trials — Testing different medication combinations and timing strategies to improve egg retrieval, fertilization rates, and pregnancy outcomes.
- Embryo selection trials — Evaluating new genetic testing or imaging methods to choose embryos with the highest chance of becoming a healthy pregnancy.
- Ovulation induction trials — Testing medications like letrozole and clomiphene to help women ovulate, often compared to see which works better for specific diagnoses.
- Male infertility trials — Studies of supplements, medications, or procedures aimed at improving sperm count, motility, or DNA quality.
- Endometriosis trials — Testing whether surgery or medication for endometriosis before attempting pregnancy improves conception rates.
Recently added Infertility trials
Take a carnitine supplement during your IVF treatment cycle
The goal of this clinical trial is to learn whether supplementation with L-carnitine improves outcomes in women undergoing in vitro fertilization (IVF). It will also evaluate the effect of supplementation on oocyte quality, embryo quality, and pregnancy rates. The main questions it aims to answer are: * Does supplementation improve the number and quality of oocytes retrieved during IVF treatment? * Does supplementation improve the number and quality of embryos obtained after fertilization? * Does supplementation increase the rates of biochemical and clinical pregnancy? Researchers will compare women receiving supplementation with women not receiving supplementation to determine whether the supplements improve IVF outcomes.
Track your endometriosis health with researchers over 24 months
Endometriosis is a chronic condition that may cause pelvic pain, ovarian cysts, infertility, and recurrent symptoms. This prospective observational cohort study will enroll women aged 18 to 45 years with endometriosis and age- and body mass index-matched healthy women. Participants will receive routine clinical care, and the study will not assign medications or procedures. Baseline clinical information will be collected, and participants will be followed for 24 months, every 3 months during the first year and every 6 months thereafter. The study will assess cyst recurrence, pain recurrence, pregnancy and live birth outcomes, and other long-term clinical outcomes. It will also evaluate associations between disease characteristics, rASRM stage, routine medical treatment, and subsequent clinical and reproductive outcomes, and will support the establishment of an endometriosis clinical research database.
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