Infertility affects about one in eight couples trying to conceive. Treatment options range from fertility drugs that stimulate ovulation to in vitro fertilization (IVF), where eggs are fertilized outside the body. Success rates vary widely based on age, cause of infertility, and treatment approach.
What's actually going on in research
Trials are testing drugs to improve egg quality and ovarian response, new approaches to male infertility including hormone treatments and antioxidants, ways to select the best embryos for transfer, and methods to preserve fertility during cancer treatment. Researchers are also studying the uterine environment and immune factors that may prevent implantation.
Male infertility treatments
Studies are testing clomiphene, letrozole, and other drugs to improve sperm count and motility in men. Antioxidant supplements and varicocele repair are also under evaluation.
Embryo selection methods
New genetic testing and imaging techniques aim to identify which embryos are most likely to result in pregnancy. These methods could reduce the number of IVF cycles needed.
Ovarian aging interventions
Researchers are testing whether supplements like coenzyme Q10 and DHEA can improve egg quality in women with diminished ovarian reserve. Results have been mixed so far.
What to know before you search
Eligibility typically depends on duration of infertility, prior treatments attempted, ovarian reserve markers, sperm parameters, and underlying diagnoses like endometriosis or PCOS.
What types of trials are currently open
- IVF protocol trials — Testing different medication regimens, trigger timing, and embryo transfer strategies to improve pregnancy rates.
- Male factor trials — Studies of medications, supplements, or procedures to improve sperm quality in men with low counts or poor motility.
- Ovulation induction trials — Testing drugs like letrozole and clomiphene to help women who don't ovulate regularly or at all.
- Fertility preservation trials — Studies of egg or sperm freezing methods, especially for people facing cancer treatment or other medical procedures.
- Implantation trials — Testing treatments to prepare the uterine lining or address immune factors that may prevent embryos from implanting.
Recently added Infertility trials
Clinical Value of Saline Infusion Sonohysterography in the Assessment of Cesarean Scar Defects
This study selected patients who underwent cesarean section and were scheduled to undergo Saline Infusion Sonohysterography (SIS) for evaluating the structure of the incision. Clinical characteristics and clinical symptoms were collected. Combined with hysteroscopy, MRI, conventional ultrasound and SIS examination results, the study analyzed the detection rate of cesarean section diverticula by SIS, the changes in diverticulum size and the diagnostic efficacy of residual muscle layer thickness at the incision site. The surgical methods and clinical symptom improvement of patients with CSD after surgery were followed up for half a year to one year. The study aimed to clarify the guiding value of SIS in clinical decision-making and patient prognosis for patients, and to analyze the etiological relationship between the true incidence of CSD and clinical complications. Thus, it provided evidence-based basis for clinical events of cesarean section surgery → CSD → CSD complications → surgical treatment of CSD → patient prognosis, promoting the progress of precise diagnosis and treatment of female reproductive health.
A Multicenter, Prospective, Randomized Controlled Clinical Study on the Effect of Hysteroscopic Uterine Septum Resection on IVF-ET Outcomes in Infertile Patients With Non-recurrent Miscarriage
This study aims to evaluate the impact of hysteroscopic transcervical resection of the septum (TCRS) on fertility in infertile women without recurrent miscarriage, primarily assessing its effect on subsequent IVF-ET outcomes. The research attempts to answer: for infertile women with uterine septum planning to undergo IVF/ICSI (excluding preimplantation genetic diagnosis), does TCRS improve pregnancy outcomes (such as live birth rate, pregnancy rate, miscarriage rate, etc.) compared to non-surgical treatment (conservative observation), and to clarify the clinical value and safety of this surgical intervention.
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