Infertility affects about one in six couples trying to conceive. Treatment options range from medication that stimulates ovulation to in vitro fertilization (IVF), where eggs are fertilized outside the body and transferred to the uterus. Success rates have improved steadily, and research is working to make treatment safer, more effective, and accessible to more people.
What's actually going on in research
Trials are testing ways to improve egg and sperm quality, develop better embryo selection methods, reduce complications like ovarian hyperstimulation, and address specific causes like endometriosis and male factor infertility. Researchers are also studying mitochondrial health in eggs, new hormonal protocols for ovulation induction, and genetic screening techniques that may improve pregnancy rates without increasing multiple births.
Embryo selection technology
New imaging and genetic testing methods aim to identify which embryos are most likely to result in pregnancy. The goal is higher success rates per IVF cycle while reducing the number of embryos transferred and avoiding multiple pregnancies.
Endometriosis treatment
Studies are testing whether treating endometriosis before IVF improves outcomes, and whether new medications can preserve fertility in women with the condition. Some trials focus on inflammation pathways that may link endometriosis to infertility.
Male factor approaches
Trials are examining antioxidant supplements, hormonal treatments, and techniques to select healthier sperm. Research is also exploring genetic causes of low sperm count and poor sperm quality.
What to know before you search
Eligibility typically depends on age, duration of infertility, ovarian reserve testing, sperm analysis results, and whether prior fertility treatments have been tried.
What types of trials are currently open
- IVF protocol trials — Testing different medication combinations and timing strategies to improve egg retrieval, fertilization rates, and pregnancy outcomes.
- Embryo selection trials — Evaluating new genetic testing or imaging methods to choose embryos with the highest chance of becoming a healthy pregnancy.
- Ovulation induction trials — Testing medications like letrozole and clomiphene to help women ovulate, often compared to see which works better for specific diagnoses.
- Male infertility trials — Studies of supplements, medications, or procedures aimed at improving sperm count, motility, or DNA quality.
- Endometriosis trials — Testing whether surgery or medication for endometriosis before attempting pregnancy improves conception rates.
Recently added Infertility trials
Share your experiences about infertility and sexual health
Fertile and infertile couples attending the Urology Unit and the Assisted Reproductive Technology (ART) Service at our Foundation will be enrolled. As part of the standard of care, all couples will undergo both a gynecological evaluation and consultation and an andrological evaluation and consultation. In accordance with routine clinical practice, infertile couples will be asked during the consultation to complete validated self-administered questionnaires designed to assess the impact of infertility on their sexual function.
Receive a dual trigger injection for egg maturation
To compare the embryological and reproductive outcomes of dual trigger versus conventional hCG trigger for final oocyte maturation in normal responder patients undergoing ICSI cycles.
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