Polycystic ovary syndrome affects roughly one in ten women of reproductive age. It involves irregular periods, elevated androgens (male hormones), and often insulin resistance. Treatment today centers on birth control pills for menstrual regulation, metformin for metabolic concerns, and lifestyle modification, but no therapy addresses the underlying cause.
What's actually going on in research
Trials are testing drugs that target insulin resistance more directly, anti-androgen medications beyond what's currently available, and treatments for the metabolic complications that often accompany PCOS. Researchers are also studying the condition's origins, including possible roles of gut bacteria and inflammation, and looking for biomarkers that might identify different PCOS subtypes requiring different approaches.
GLP-1 receptor agonists
Drugs like semaglutide and liraglutide, developed for diabetes and obesity, are being tested in PCOS for their effects on weight, insulin resistance, and menstrual regularity. Early studies suggest they may restore ovulation in some women.
Inositol compounds
Myo-inositol and D-chiro-inositol, supplements that affect insulin signaling, are being studied for their ability to improve metabolic parameters and ovulation. Several trials are testing optimal doses and combinations.
Anti-androgen therapies
Beyond spironolactone, newer selective androgen receptor modulators are being tested. These aim to block the effects of excess male hormones with fewer side effects than current options.
What to know before you search
Eligibility typically depends on PCOS diagnostic criteria met, whether pregnancy is desired, BMI, presence of insulin resistance or diabetes, and current medications.
What types of trials are currently open
- Metabolic trials — Testing drugs like metformin, GLP-1 agonists, and inositol for their effects on insulin resistance, weight, and metabolic health in women with PCOS.
- Fertility trials — Comparing medications that induce ovulation, including letrozole and clomiphene, and testing newer approaches to help women with PCOS conceive.
- Hormonal trials — Testing birth control formulations and anti-androgen drugs for managing irregular periods, acne, and excess hair growth.
- Lifestyle intervention studies — Studying the effects of specific diets, exercise programs, and behavioral approaches on PCOS symptoms and metabolic outcomes.
Recently added Polycystic Ovary Syndrome trials
Complete brain imaging scans to advance PCOS research
The purpose of this study is to determine how polycystic ovary syndrome (PCOS) impacts overall brain health, such as cerebral blood flow (CBF), brain structure and connectivity, and cognitive performance. 45 reproductive aged (18-45 years) individuals with ovaries, with and without PCOS, will be enrolled to complete brain structure and CBF scans via magnetic resonance imaging (MRI) over 2 testing visits and can expect to be on study for approximately 5 hours over a 1 to 3 month period.
Try breathing exercises to help sleep problems from PCOS
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in females in reproductive age and not completely understood. Women with PCOS appear to have an increased frequency of sleep problems. Diaphragmatic Breathing (DB) exercises has positive effects on improving sleep quality. The purpose of this study will evaluate the effect of diaphragmatic breathing exercises on improving sleep quality in polycystic ovarian syndrome women.
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