A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression

Completed

Plain-English translation of NCT02418585 on ClinicalTrials.gov ↗ · Source last updated April 2025 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

Trial locations(48 sites)

United States

Birmingham, Alabama

Orange, California

San Rafael, California

Maitland, Florida

Atlanta, Georgia