Plain-English translation of NCT02478892 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Pancreatic Cancer research guide →This trial is evaluating whether endoscopic ultrasound—a specialized imaging technique that uses sound waves to look at the pancreas from inside the stomach—can help detect pancreatic cancer at an earlier, more treatable stage in people who carry inherited genetic mutations that put them at higher risk. The study aims to see if screening people with these genetic changes can catch cancer when it's still small and potentially curable, rather than waiting for symptoms to appear.
Pancreatic cancer is often found too late to treat effectively in the general population, so screening everyone is not practical. However, people who inherit certain genetic mutations have a much higher lifetime risk of developing pancreatic cancer, making them good candidates for regular screening that might catch the disease early when treatment options are better.
You likely qualify if…
You likely don't qualify if…
If you qualify, you would receive regular endoscopic ultrasound screening exams, which involve a thin tube with an ultrasound probe being passed through your mouth into your stomach to take detailed pictures of your pancreas. The study team will monitor your pancreas over time to look for any signs of cancer and provide you with the results. The exact number and timing of visits would be discussed with the research team at Penn Medicine.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
United States
Sponsor
Abramson Cancer Center at Penn Medicine
Enrollment target
~200 participants
Started
May 2015
Primary completion
May 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2026.
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Central contact
Bryson Katona, MD
Abramson Cancer Center at Penn Medicine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.