Plain-English translation of NCT02531880 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Epilepsy research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This research study is testing whether two types of advanced brain imaging—one using a contrast dye called and one using —can help doctors identify where seizures start in people whose epilepsy doesn't respond to standard medications. Researchers want to understand if these imaging methods are safe and whether they can show changes in the brain's protective barrier that might be related to hard-to-control seizures.
About one-third of people with epilepsy continue to have seizures even with the best available medications. Researchers need better ways to locate where seizures begin in the brain so doctors can plan more targeted treatments like surgery. This study is exploring whether these new imaging methods can reveal clues that standard imaging misses.
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Participants will undergo screening visits including blood and urine tests and a baseline brain MRI scan. Depending on which arm of the study they join, they will receive an injection of contrast dye (either or ) followed by a series of brain MRI scans. Some participants may stay in the hospital for continuous EEG monitoring to capture brain activity during or right after a seizure, while others will have scans done between seizures as outpatients.
AI-generated summary from trial data · Sep 16, 2026 · Not medical advice
United States