Donate blood samples and complete screening tests for prostate cancer risk

Donate blood samples and complete screening tests for prostate cancer risk | stella

What is this trial?

The PROFILE Study is looking at how genetic information—the inherited instructions that make up who you are—can help doctors screen for prostate cancer more accurately. Researchers will collect blood and urine samples from men at higher genetic risk of prostate cancer and compare genetic profiles with screening results and biopsies to understand which men truly need treatment and which screening methods work best.

Prostate cancer screening tests like the PSA blood test don't always give clear answers, and doctors aren't sure how to best screen men who are at higher risk because of their genes or family history. This study aims to find better ways to identify who actually needs a prostate biopsy and treatment, rather than screening everyone the same way.

Do you qualify?

You likely qualify if…

you are between 40 and 69 years old
you have a family history of prostate cancer (a close relative diagnosed before age 70, or multiple relatives with prostate cancer)
you are of Black African or Black African-Caribbean ancestry (both parents and all four grandparents from these backgrounds)
you carry a known genetic mutation that increases prostate cancer risk (such as BRCA1, BRCA2, or others)
you have a high genetic risk score based on multiple inherited factors

You likely don't qualify if…

you have had prostate cancer before
you had a negative prostate biopsy within the past year
you are taking blood-thinning medications like warfarin or other anticoagulants
you have an MRI-incompatible medical device (such as certain pacemakers or metal implants)
you have a body mass index (BMI) of 40 or higher, or BMI of 35 or higher with other serious health conditions

What participation looks like

You will donate blood and urine samples for genetic testing and biomarkers, and you may have imaging scans like MRI performed. Some participants will also receive a prostate biopsy—a procedure where a small tissue sample is taken from the prostate. The study follows an observational approach, meaning researchers will track your results over time to see how genetic information correlates with screening findings and prostate cancer detection, rather than testing a new medication.

AI-generated summary from trial data · Jul 9, 2026 · Not medical advice

Genetic screening to improve prostate cancer detection in high-risk men

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)