Plain-English translation of NCT03484299 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a combination of two treatments for advanced pancreatic cancer: irreversible electroporation (a procedure that uses electrical pulses to destroy cancer cells) and chemotherapy. All participants will receive the electric pulse treatment along with one of two chemotherapy options—either or —depending on which medication they received before the procedure.
Most people with advanced pancreatic cancer cannot have their tumors completely removed by surgery, which limits treatment options. This trial explores whether combining electric pulse technology with standard chemotherapy might help control the cancer better than chemotherapy alone.
You likely qualify if…
You likely don't qualify if…
You will receive chemotherapy before and after a procedure in which electrical pulses are delivered to your pancreatic tumor to destroy cancer cells. The procedure requires brief anesthesia and may be performed in an operating room or specialized procedure suite. You will have follow-up visits to monitor your recovery, check your tumor response through imaging, and manage any side effects from both the chemotherapy and the electric pulse treatment.
AI-generated summary from trial data · Aug 11, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
University of Louisville
Enrollment target
~20 participants
Started
May 2018
Primary completion
July 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in October 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Robert Martin, MD, PhD
University of Louisville
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.