Plain-English translation of NCT03888924 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether Bacille Calmette-Guérin (BCG) vaccine — a vaccine that's been used safely for over a century — can help stop multiple sclerosis from developing in people who have early warning signs visible on brain MRI scans but haven't experienced any MS symptoms yet. You would receive either one dose of the vaccine or a placebo (a fake vaccine), and researchers would follow you to see whether this treatment slows down or prevents MS from starting.
Most MS treatments work best when given very early in the disease, but many people don't get treated until they have symptoms. This trial is testing whether this medication could be a safe, affordable way to prevent MS from ever starting in people who show early brain changes — potentially stopping the disease before it causes real problems.
You likely qualify if…
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You would visit the study center to receive either one dose of the vaccine or a placebo injection. The researchers would then follow you over time with MRI brain scans and medical assessments to see whether the treatment helps prevent MS symptoms from developing. The study involves 100 participants total, and you would be monitored to track any changes in your condition and ensure your safety.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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