Plain-English translation of NCT04048278 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Pancreatic Cancer research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers are testing whether , a numbing medication commonly used in anesthesia, might help reduce cancer cells that circulate in the blood during pancreatic cancer surgery. You would receive either the medication or a placebo (salt water) through an IV starting in the operating room and continuing for 24 hours afterward. The study will examine whether this treatment affects cancer cells in your bloodstream.
During pancreatic cancer surgery, cancer cells can enter the bloodstream and potentially spread disease. Early research suggests that this medication might slow down or reduce these circulating cancer cells, which could improve outcomes for patients with pancreatic cancer.
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You would be randomly assigned to receive either the medication or placebo before your scheduled pancreatic cancer surgery. The IV infusion begins in the operating room and continues for 24 hours after surgery. During this time, the research team will collect blood samples at different points to study how the treatment affects cancer cells in your bloodstream. The study involves blood draws but no additional procedures beyond your planned surgery.
AI-generated summary from trial data · Jun 15, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
University of Illinois at Chicago
Enrollment target
~46 participants
Started
November 2018
Primary completion
November 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in June 2026.
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Central contact
Alexandra Barabanova, MS
Associate Professor
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