Plain-English translation of NCT04287088 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new approach to prostate cancer diagnosis for men who have signs of possible prostate cancer (high PSA levels or abnormal physical exams). Instead of automatically biopsying every man's prostate, doctors will first perform an MRI scan of the prostate, then work with you to decide whether a biopsy is truly needed based on what the scan shows and your personal risk.
Currently, many men receive prostate biopsies even when their MRI scans look normal, leading to unnecessary procedures and detection of cancers that may never cause harm. This trial is testing whether letting patients and doctors make shared decisions about biopsy—based on clear MRI findings and cancer risk—can catch the dangerous cancers while sparing men from unnecessary biopsies.
You likely qualify if…
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After you enroll and consent, you will have an MRI scan of your prostate. Depending on which study group you're randomly assigned to, your care will differ: in one group, all men receive a prostate biopsy after the MRI; in the other group, you and your doctor will discuss whether a biopsy is necessary based on your MRI results and personal cancer risk, and you may skip the biopsy if the risk is very low. If you do receive a biopsy, it will be performed using ultrasound guidance, and the number of samples taken will depend on what the MRI showed.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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