Plain-English translation of NCT04337580 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether omeprazole, a medication that works differently than typical cancer drugs, can help improve the effectiveness of cabazitaxel (a chemotherapy) in men with advanced prostate cancer that has already stopped responding to previous treatment. Researchers want to see if combining these two medications together can shrink tumors or stop cancer growth better than the chemotherapy alone.
Men with castration-resistant prostate cancer that has already been treated with chemotherapy have few remaining options, and the cancer often becomes harder to treat. This trial explores whether this medication might tackle cancer cells in a new way that could help more patients respond to their treatment.
You likely qualify if…
You likely don't qualify if…
You would visit the clinic on an outpatient basis to receive cabazitaxel chemotherapy (the standard treatment) while taking omeprazole tablets twice daily at home. The trial will track how your cancer responds using imaging and blood tests (PSA levels), and you'll complete surveys about your pain and quality of life at several checkpoints throughout treatment. The study involves about 50 patients total, and you can continue as long as the treatment is helping and you're tolerating it well.
AI-generated summary from trial data · Jul 21, 2026 · Not medical advice
United States