Plain-English translation of NCT04346225 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new imaging technique called hyperpolarized pyruvate MRI, which creates detailed pictures of prostate cancer tumors to see how they're responding to your current cancer treatment. The scan measures how cancer cells are using energy, which may help doctors predict whether your treatment is working before traditional imaging shows a change. Researchers hope this new scan will help them understand your cancer better and guide treatment decisions.
Current imaging methods sometimes can't tell quickly enough whether prostate cancer treatment is working. This trial aims to develop a faster, more accurate way to spot whether treatment is helping, so doctors can adjust your care sooner if needed.
Depending on which study group you join, you will receive one or more specialized MRI scans of your cancer tumor, with injections of the imaging agent on the day of each scan. Some participants will have a single scan (Cohort A), while others will have scans at the start and again 12 weeks later, plus possibly an additional scan if your cancer progresses (Cohort B). The study may also include optional tumor biopsies to help researchers understand more about your cancer. Most visits will involve MRI imaging lasting several hours, and you'll be asked to follow up with the study team to track how your cancer responds to treatment.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
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