Plain-English translation of NCT04356664 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Endometriosis research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This study is testing whether Decapeptyl, a hormone injection, can improve your chances of pregnancy when combined with standard embryo transfer treatment. The medication is given about one month before your frozen embryo is transferred into your uterus. Researchers believe this treatment may reduce inflammation in the uterus that occurs with endometriosis or adenomyosis, making it easier for an embryo to implant and grow.
Endometriosis and adenomyosis cause inflammation and changes in the uterus that make it harder for embryos to implant and grow. This medication may reduce that inflammation, giving women with these conditions a better chance of successful pregnancy with frozen embryo transfer.
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You will be randomly assigned to one of two groups: one receiving standard hormone replacement therapy before embryo transfer, and the other receiving one or two injections of the medication about one month before transfer, plus the same standard hormone therapy. You'll have an MRI scan during enrollment to confirm your diagnosis. The study involves regular clinic visits for blood tests and ultrasounds as part of standard fertility care, culminating in your frozen embryo transfer procedure.
AI-generated summary from trial data · Aug 22, 2026 · Not medical advice
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