Plain-English translation of NCT04451278 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Epilepsy research guide →This trial is testing whether a special type of brain scan called resting-state functional MRI can predict how well surgery will work for children with drug-resistant epilepsy. The scan captures how different parts of your brain communicate with each other while you're at rest. By studying these brain networks, doctors hope to better understand which children will benefit most from surgery and how their brain might recover afterward.
Many children with drug-resistant epilepsy need surgery to control their seizures, but doctors currently have limited ways to predict whether surgery will succeed or how well a child will recover. This study aims to fill that gap by using advanced brain imaging to identify which patients are most likely to have good outcomes and preserve important skills like speech and vision.
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You would receive an MRI scan with one additional special sequence added to the standard imaging — this resting-state scan happens before any contrast dye is injected and requires you to simply lie still in the scanner without doing any particular task. Before your surgery, you would also complete a neuropsychological evaluation (thinking and language tests) to establish a baseline, which doctors will use to track any changes in your abilities after surgery. The study team will follow your recovery progress for about six months after your procedure.
AI-generated summary from trial data · Jul 4, 2026 · Not medical advice
France
Sponsor
Fondation Ophtalmologique Adolphe de Rothschild
Enrollment target
~200 participants
Started
October 2020
Primary completion
October 2027
Age range
6 Years – 18 Years
Last updated on clinicaltrials.gov in January 2026.
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Central contact
Sidney KRYSTAL
Adolphe de Rothschild Fondation Hospital
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