A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC)

Active, not recruiting

Plain-English translation of NCT04497844 on ClinicalTrials.gov ↗ · Source last updated September 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

Trial locations(387 sites)

United States

Urology Centers Of Alabama, Homewood, Alabama

Mayo Clinic Arizona, Phoenix, Arizona

Urological Associates of Southern Arizona, P.C., Tucson, Arizona

Greater Los Angeles VA Healthcare System, Los Angeles, California

University of California Irvine Medical Center Chao Family Comprehensive Cancer Center, Orange, California