Plain-English translation of NCT04607174 on ClinicalTrials.gov ↗ · Source last updated · Translation generated ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is investigating how well the thigh muscle (quadriceps) can activate—or recruit its fibers—in people with movement or nerve disorders such as stroke, multiple sclerosis, Parkinson's disease, or knee injuries. Researchers will measure your muscle activation using a specialized machine and a brief electrical stimulation technique to understand whether weakness comes from the brain not signaling the muscle properly, or from damage to the muscle or joint itself.
People with neurological and orthopedic conditions often experience weakness, but doctors don't always know whether that weakness is caused by the brain failing to recruit the muscle fibers, or by damage to the tissues themselves. Understanding this difference could help guide better treatments in the future.
You likely qualify if…
You likely don't qualify if…
You will visit the research center for a session where researchers will measure how well your thigh muscle activates during two types of contractions: one while your leg is held steady, and another while your leg moves at a controlled speed on a special machine called an isokinetic dynamometer. During the test, you'll receive a brief electrical stimulation to your thigh muscle to help the researchers understand whether all the muscle fibers are being recruited. The entire visit typically takes a few hours.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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