Plain-English translation of NCT04737187 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal cancer research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
The SUNLIGHT trial tested whether combined with worked better than alone for patients with advanced colorectal cancer that had stopped responding to earlier treatments. About 490 patients were randomly assigned to receive either the medication combination or the single medication. The trial was designed to find out if adding this second drug could help patients live longer and feel better.
Colorectal cancer that has spread and stopped responding to standard treatments is very serious, and patients need better options. This trial investigated whether combining two different medications could be more effective than using one alone in helping patients when other treatments have failed.
Participants were randomly assigned to one of two groups. Both groups took oral medication twice daily for 5 days on, then 2 days off, repeating this pattern over 2 weeks, followed by a 2-week rest—completing a 4-week cycle. One group received only this oral medication, while the other group also received intravenous infusions of a second medication every 2 weeks. Participants continued this treatment cycle until the cancer progressed or side effects became too severe, with regular visits for monitoring and blood tests.
AI-generated summary from trial data · Oct 12, 2026 · Not medical advice
United States